Related Experiment Video
Updated: Jul 17, 2026
Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
Published on: January 16, 2019
[Clinical epidemiology of 1,087 patients with multiple organ dysfunction syndrome]
Shu-wen Zhang1, Hong Wang, Qiang Su
1Department of Infectiouse Diseases and Critical Care Medicine, Beijing Friendship Hospital Affiliated of Medical Science, Beijing, China.
Objective:
To investigate the clinical epidemiological characteristics of multiple organ dysfunction syndrome (MODS) in China.
Methods:
A multiple-center and prospective survey of the patients with MODS admitted to 37 hospitals in 11 provinces from March 2002 to January 2005.
Results:
The original causes of the MODS were still severe infection, major operations, shock, cardio-pulmonary resuscitation, trauma, and severe acute pancreatitis. The age of 66.1% patients was over 60 years in 1 087 patients. The total mortality of the 1 087 patients was 60.4%. With the age increased, the mortality also increased. The mortalities of the group with simple dysfunction of the brain, lung, kidney, blood, cardiovascular system and gastrointestinal tract were higher than those of the group with the normal organ function. The mortality increased obviously with the numbers of the dysfunction organs. The methods of supportive treatment for the dysfunctional organs were more sophisticated than before. Especially the rates of administration of blood purification, parenteral alimentation, and enteral alimentation were higher.
Conclusion:
Although the methods of supportive treatment in the dysfunctional organs are more sophisticated, the mortality of the MODS was still as high as 60.4%. The number of patients with age higher than 60 years was 713 cases (66.1%), therefore how to manage senile-MODS has become a major problem. Cardiovascular system, the brain, kidney, gastrointestinal tract, lung, liver and blood were the main organs involved, and the mortality of dysfunction of cardiovascular system ranked the highest.
Insights
Multiple organ dysfunction syndrome (MODS) in China has a high mortality rate of 60.4%, particularly in patients over 60. Cardiovascular dysfunction carries the highest mortality risk.
Area of Science:
- Critical Care Medicine
- Epidemiology
- Internal Medicine
Context:
- Multiple organ dysfunction syndrome (MODS) poses a significant challenge in critical care.
- A prospective, multi-center survey was conducted across 37 hospitals in China.
- Data was collected from March 2002 to January 2005.
Purpose:
- To investigate the clinical epidemiological characteristics of MODS in China.
- To identify primary causes and risk factors associated with MODS.
- To analyze mortality rates and affected organs in MODS patients.
Summary:
- Severe infection, major operations, shock, and trauma were leading causes of MODS.
- 66.1% of 1,087 patients were over 60 years old, with age correlating to increased mortality.
- Overall mortality was 60.4%, with cardiovascular dysfunction having the highest fatality rate.
Impact:
- Despite advanced supportive treatments like blood purification and alimentation, MODS mortality remains high.
- Managing MODS in elderly patients (over 60) presents a major clinical problem.
- Understanding MODS epidemiology is crucial for developing targeted interventions and improving patient outcomes.
Related Concept Videos
01:29Acute Kidney Injury III: Clinical Manifestations
01:24Chronic Kidney Disease II: Clinical Manifestations
01:29Acute Kidney Injury II: Pathophysiology
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention