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Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
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TRB3 modulates C2C12 differentiation by interfering with Akt activation.

Satomi Kato1, Keyong Du

  • 1The Molecular Oncology Research Institute, Tufts-New England Medical Center, 750 Washington St., Boston, MA 02111, USA.

Biochemical and Biophysical Research Communications
|January 9, 2007
PubMed
Summary

The study reveals that the protein Tribbles homolog 3 (TRB3) is downregulated during muscle differentiation. TRB3 inhibits Akt activation, suppressing muscle cell differentiation, while its knockdown enhances it.

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