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Related Experiment Videos

Multifunctional cargo systems for biotechnology.

Gleb B Sukhorukov1, Helmuth Möhwald

  • 1Department of Materials, Queen Mary University of London, Mile End Road, London, E1 4NS, UK. g.sukhorukov@qmul.ac.uk

Trends in Biotechnology
|January 9, 2007
PubMed
Summary
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Developing functional nano-sized delivery systems, like layer-by-layer capsules, is key in bio-nanotechnology for targeted drug delivery. These advanced biomaterials offer controlled release and potential in vivo applications.

Area of Science:

  • Bio-nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Developing functional nano-sized delivery systems is a significant challenge in bio-nanotechnology.
  • Layer-by-layer assembled capsules are versatile for encapsulating bioactive substances and offer tunable functionalities.

Purpose of the Study:

  • To explore the potential of nano-sized capsules as advanced delivery systems.
  • To discuss current research in remote-guided and activated carriers for in vivo applications.
  • To highlight the use of submicron capsules as models for cellular processes and as potential intracellular reactors.

Main Methods:

  • Review of layer-by-layer capsule assembly techniques.
  • Analysis of functionalization strategies for enhanced payload delivery.

Related Experiment Videos

  • Investigation of remote activation methods (optical, magnetic, ultrasound).

    • Main Results:

    • Layer-by-layer capsules demonstrate high adaptability for modification and encapsulation.
    • Remote-controlled carriers show promise for targeted in vivo applications.
    • Submicron capsules can mimic cellular organelles and function as reporters or reactors.

    Conclusions:

    • Nano-sized capsules, particularly layer-by-layer assembled ones, offer significant potential in bio-nanotechnology for targeted delivery and controlled release.
    • Further research is needed to overcome existing obstacles for clinical implementation of capsule technology.
    • Multifunctional biomaterials with remote guiding and activation capabilities are paving the way for novel in vivo applications.