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Published on: August 14, 2016
1-O-alkylglycerols reduce the stimulating effects of bFGF on endothelial cell proliferation in vitro
Frédérique Pédrono1, Bernard Saïag, Jacques-Philippe Moulinoux
1Laboratoire de Pharmacologie Moléculaire, Faculté de Pharmacie, Université de Rennes I, Rennes, France.
Abstract:
1-O-alkylglycerols (alkyl-Gro) are natural etherlipids with multiple biological activities. We previously demonstrated that alkyl-Gro reduce endothelial permeability. Here we showed that alkyl-Gro reduced the basic Fibroblast Growth Factor (bFGF)-stimulated endothelial cell proliferation in a concentration-dependent manner. The effects of 0.5 and 5 ng/ml bFGF on growth were completely suppressed after 72 h-treatment by 50 microM alkyl-Gro. Since bFGF greatly increased (+56%+/-15) the production of 1-O-alkyl-2-acyl-sn-glycerophosphate in alkyl-Gro-treated endothelial cells, our data suggest that the observed effects of alkyl-Gro could be mediated through PLD activation. Inhibition of bFGF-stimulated endothelial proliferation could support anti-angiogenic activity of alkyl-Gro.
