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Updated: Jul 17, 2026

Extraction of Tissue Antigens for Functional Assays
Published on: September 10, 2012
Tissue-polypeptide-specific antigen levels in diabetic patients with normal and pathological biochemical profiles
Javier Rodriguez1, Rubén Varela-Calviño, Manuel Garrido Outeiriño
1Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, Spain.
Objectives:
To identify causes for the raised TPS levels seen in diabetic patients.
Design And Methods:
Relationships between TPS levels and biochemical markers for glycaemic control, hepatic dysfunction and renal dysfunction were investigated in 402 diabetic patients, none with evidence of cancer.
Results:
Median TPS level (range) was 34.6 (19-276) U/L in controls versus 40.5 (16-691) U/L in type 1 diabetes mellitus (T1DM) patients and 53 (6-1654) U/L in type 2 diabetes mellitus (T2DM) patients. TPS levels above the 95th percentile were observed in 26.1% diabetic patients and in 68.6% of these diabetic patients, raised TPS was associated with clinical complications or biochemical indicators of hepatic and/or renal dysfunction.
Conclusions:
The raised mean TPS levels seen in diabetic patients appear to be mainly due to the existence of hepatic or renal dysfunction.
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