Related Experiment Video

Updated: Jul 17, 2026

Conducting Respiratory Oscillometry in an Outpatient Setting
14:49

Conducting Respiratory Oscillometry in an Outpatient Setting

Published on: April 8, 2022

Active breathing control for Hodgkin's disease in childhood and adolescence: feasibility, advantages, and limits

Line Claude1, Claude Malet, Pascal Pommier

  • 1Department of Radiotherapy, Centre Léon Bérard, Lyon, France. claude@lyon.fnclcc.fr

International Journal of Radiation Oncology, Biology, Physics
|January 9, 2007
PubMed

Insights

Active breathing control (ABC) is feasible in children with Hodgkin's disease (HD), reducing lung irradiation. This technique shows minimal benefit for heart dose and no significant change for breast or thyroid doses.

Area of Science:

  • Pediatric Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Early-stage Hodgkin's disease (HD) in children requires treatment balancing survival with organ sparing.
  • Minimizing radiation dose to healthy tissues is crucial to reduce long-term side effects in pediatric cancer patients.

Purpose of the Study:

  • To assess the feasibility of active breathing control (ABC) in pediatric patients with HD.
  • To compare normal tissue irradiation, specifically lungs, heart, breasts, and thyroid, with and without ABC during radiation therapy planning.

Main Methods:

  • Seven children with HD and mediastinal involvement underwent CT simulation with free-breathing and ABC.
  • Treatment plans were compared for clinical target volumes including supraclavicular regions, mediastinum, and hila.
  • Pulmonary, cardiac, breast, and thyroid doses were analyzed based on dose-volume histograms.

Main Results:

  • ABC significantly reduced the mean lung volume irradiated at 20 Gy (V20) by 25% and at 30 Gy (V30) by 26% (p=0.016).
  • A non-significant reduction in heart irradiation was observed.
  • Mean doses to breasts and thyroid remained low and showed no significant difference with or without ABC.

Conclusions:

  • Active breathing control is a feasible technique for pediatric patients with HD.
  • ABC effectively reduces radiation dose to normal lung tissue.
  • While minimal cardiac dose reduction was noted, ABC did not significantly impact breast or thyroid doses.
Abstract

Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Respiratory Assessment: Purpose and Indications01:19

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic sinusitis...