Related Experiment Video
Updated: Jul 17, 2026
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Characterization and activity of sonochemically-prepared BSA microspheres containing Taxol--an anticancer drug
Olga Grinberg1, Michal Hayun2, Benjamin Sredni2
1Department of Chemistry and Kanbar Laboratory for Nanomaterials at the Bar-Ilan University, Center for Advanced Materials and Nanotechnology, Bar-Ilan University, Ramat-Gan, 52900, Israel.
Abstract:
Proteinaceous microspheres of BSA (Bovine Serum Albumin) containing an anticancer drug, Taxol (paclitaxel) were fabricated using a sonochemical procedure and then assayed for chemical and biological activity. The sonochemical reaction did not compromise the drug, which became encapsulated in the BSA microspheres. The amount of the anticancer drug in the microspheres was determined by HPLC. Anticancer activity of the proteinaceous microspheres encapsulating the Taxol was tested on Mouse Multiple Myeloma cell line MPC-11. The influence of the Taxol microspheres on the cancer cells was different from pristine Taxol. It was found that Taxol in combination with the organic solvent causes the death of cancer cells.
