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Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
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Published on: February 24, 2014

Cytogenetic characterization of radiosensitive mouse mutants

P P van Buul1, A Tuinenburg-Bol Raap, H J Goudzwaard

  • 1MGC, Department of Radiation Genetics and Chemical Mutagenesis, Leiden, The Netherlands.

Mutation Research
|December 1, 1991
PubMed

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...