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Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells
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Therapeutic potential of Aurora kinase inhibitors in cancer

Krishna S Naruganahalli1, Manikandan Lakshmanan, Sunanda G Dastidar

  • 1Ranbaxy Research Laboratories, Pharmacology, New Drug Discovery Research, Plot 20, Sector 18 Gurgaon 122 015, India. naruganahalli.krishna@ranbaxy.com

Current Opinion in Investigational Drugs (London, England : 2000)
|January 11, 2007
PubMed

Insights

Aurora kinases (AKs) are crucial for cell division and are linked to cancer. This review explores AKs

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Aurora kinases (AKs) are serine/threonine protein kinases.
  • AKs play a critical role in regulating mitotic processes during cell division.
  • Dysregulation and overexpression of AKs are associated with various cancers, making them promising therapeutic targets.

Purpose of the Study:

  • To review the role of Aurora kinases in cancer.
  • To discuss the current status of Aurora kinase inhibitors.
  • To evaluate the therapeutic potential of Aurora kinase inhibitors in cancer treatment.

Main Methods:

  • Literature review of studies on Aurora kinases and cancer.
  • Analysis of the role of AKs in different stages of mitosis.
  • Examination of the mechanisms and clinical efficacy of AK inhibitors.

Main Results:

  • Aurora kinases are key regulators of mitosis, including centrosome duplication, spindle formation, chromosome alignment, and cytokinesis.
  • Overexpression of AKs is frequently observed in various cancer cell lines and human malignancies.
  • Several Aurora kinase inhibitors are under investigation, showing promise in preclinical and clinical studies.

Conclusions:

  • Aurora kinases are crucial for cell division and their aberrant expression is linked to cancer development.
  • Targeting Aurora kinases with inhibitors represents a viable strategy for anticancer drug development.
  • Further research into AK inhibitors may lead to novel therapeutic approaches for cancer treatment.

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