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Fatal mephenesin intoxication.

Laurent Fanton¹, Fabien Bévalot, Patrice Schoendorff

¹Institut Universitaire de Médecine Légale, de Lyon Université, Claude-Bernard Lyon1, 12 avenue Rockefeller, 69008 Lyon, France. laurent.fanton@adm.univ-lyon1.fr

Journal of Forensic Sciences

|January 11, 2007

Summary

This is the first reported case of a fatal mephenesin overdose. The 48-year-old woman

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Area of Science:

Forensic Toxicology
Clinical Toxicology
Pharmacology

Background:

Mephenesin is a muscle relaxant.
Drug abuse and intoxication can lead to severe health consequences.

Observation:

A 48-year-old woman was found deceased.
Initial toxicological tests were negative; autopsy revealed bronchial inhalation syndrome.
Mephenesin was detected in autopsy samples at high concentrations.

Findings:

This is the first reported case of lethal intoxication solely due to mephenesin.
Mephenesin blood concentration was 15.81 microg/mL, significantly exceeding therapeutic levels.
Cause of death was determined to be bronchial inhalation syndrome secondary to mephenesin overdose.

Implications:

Highlights the potential for mephenesin overdose and toxicity.
Underscores the importance of comprehensive toxicological analysis in unexplained deaths.
Suggests the need for awareness regarding the abuse potential of mephenesin.