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Related Experiment Video

Updated: Jul 17, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

Propofol versus sevoflurane: bleeding in endoscopic sinus surgery.

Achim G Beule¹, Frank Wilhelmi, Thomas S Kühnel

¹Department of Otorhinolaryngology-Head and Neck Surgery, University of Greifswald, Greifswald, Germany. achim.beule@uni-greifswald.de

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery

|January 11, 2007

Summary

This study found that both sevoflurane/fentanyl and propofol/fentanyl anesthesia provide similar blood loss and endoscopic vision during surgery. However, propofol anesthesia showed more significant impairment of platelet function, which may be clinically relevant in longer procedures.

Related Experiment Videos

Last Updated: Jul 17, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

Area of Science:

Anesthesiology
Otolaryngology

Background:

Intraoperative bleeding reduction is crucial for surgical visibility and complication avoidance.
Chronic rhinosinusitis with nasal polyps often requires surgical intervention with careful anesthetic management.

Purpose of the Study:

To compare the effects of sevoflurane/fentanyl versus propofol/fentanyl anesthesia on intraoperative bleeding and endoscopic vision.
To evaluate the impact of these anesthetic regimens on platelet function.

Main Methods:

A prospective, controlled, randomized, double-blinded study involving 46 patients with chronic rhinosinusitis and nasal polyps.
Patients were randomized to receive either sevoflurane/fentanyl or propofol/fentanyl sedation.
Evaluated parameters included total blood loss, blood loss per minute, platelet function, and endoscopic vision.

Main Results:

No significant differences were observed between the two anesthetic groups in total blood loss, blood loss per minute, or endoscopic vision.
Platelet function was impaired in both groups 45 minutes after surgery onset.
Propofol anesthesia demonstrated a more pronounced impairment of platelet function compared to sevoflurane/fentanyl.

Conclusions:

Both anesthetic regimens can achieve comparable blood loss and endoscopic vision under balanced circulatory conditions.
Propofol-induced thrombocyte (platelet) impairment may have clinical significance during extended surgical procedures.