Assessment of myocardial microvascular function: new opportunities in fast computed tomography

It has been increasingly recognized that the initial site of cardiac damage in several forms of cardiovascular disease resides in the microcirculation. Noninvasive or minimally invasive evaluation of myocardial microvascular functional attributes, such as myocardial perfusion or microvascular permeability, could be an invaluable tool in the clinical practice. Advances in the field of computed tomography over the past three decades culminated in the advent of fast scanners, which show promise to provide both fine cardiac anatomic detail and quantification of the function of the myocardial microcirculation. This review describes the approach and utility of measurements of myocardial microvascular function obtained with state-of-the-art cardiac computed tomography.