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Biomaterials for sinus implantation.

Richard R Orlandi1

  • 1Center for Therapeutic Biomaterials, Division of Otolaryngology-Head and Neck Surgery, The University of Utah, USA. richard.orlandi@hsc.utah.edu

Current Opinion in Otolaryngology & Head and Neck Surgery
|January 11, 2007
PubMed
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Biomaterials in sinus surgery require careful consideration. Postmarketing data reveal potential risks like infection and scarring with hydroxyapatite cement, thrombin-gelatin paste, and hyaluronan derivatives.

Area of Science:

  • Otorhinolaryngology
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Biomaterials are integral to paranasal sinus surgery for hemostasis, tissue regeneration, healing, and scar prevention.
  • Prospective evaluation of biomaterials before commercialization is limited.
  • This review focuses on recent biomaterial advancements and postmarketing concerns in surgical rhinology.

Purpose of the Study:

  • To review recent advancements in biomaterials utilized in surgical rhinology.
  • To highlight postmarketing concerns associated with these biomaterials.
  • To emphasize the need for rigorous evaluation of biomaterials in paranasal sinus applications.

Main Methods:

  • Review of recent literature on biomaterials in surgical rhinology.

Related Experiment Videos

  • Analysis of prospective and postmarketing data for key biomaterials.
  • Evaluation of safety and efficacy data, including complications.

    • Main Results:

    • Hydroxyapatite cement use in the frontal sinus is questioned due to late infection and exposure risks.
    • Thrombin-gelatin paste shows hemostatic efficacy but conflicting data exist on its impact on scarring.
    • Hyaluronan derivatives also raise concerns regarding increased scarring, with chemical modifications influencing compatibility.

    Conclusions:

    • Surgeons must be aware of the risks and limitations of current rhinology biomaterials.
    • While advancements are expected, existing materials represent an initial phase of development.
    • Rigorous prospective evaluation is crucial to guide the optimal use of biomaterials in paranasal sinus surgery.