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Updated: Jul 17, 2026
Synthesis of an In vivo MRI-detectable Apoptosis Probe
Published on: July 31, 2012
Optical and magnetic resonance imaging of cell death and platelet activation using annexin a5-functionalized quantum
Lenneke Prinzen1, Robbert-Jan J H M Miserus, Anouk Dirksen
1Department of Biophysics, University of Maastricht, and Department of Radiology, University Hospital Maastricht, The Netherlands. L.Prinzen@bf.unimaas.nl
Abstract:
A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r1) of 3000-4500 mM-1 s-1 per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies.
