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Updated: Jul 17, 2026
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Topiramate in frontal lobe epilepsy
A Verrotti1, V Sofia, E Franzoni
1Department of Pediatrics, University of Chieti, Chieti, Italy. averrott@unich.it
Background:
Frontal lobe epilepsy (FLE) is a type of epilepsy that is difficult to treat and there are few studies about the use of topiramate (TPM).
Aim Of The Study:
To evaluate the efficacy and tolerability of TPM monotherapy in FLE.
Methods:
The study group consisted of 55 (33 male; 22 female) patients. TPM was administered as a first drug (n = 16) or converted after previous treatment (n = 39). All patients were followed every 3 months for at least 1 year. The patients were subdivided into two groups: 'newly diagnosed' patients and 'difficult-to-treat' patients.
Results:
Overall, all patients completed the 1-year study. At the end of follow-up, 10 patients showed disappearance of seizures and 33 patients showed improvement in seizure frequency. In particular, among the newly diagnosed patients 6/16 patients showed complete cessation of seizures and 5/16 patients showed very good response; in the other group, 4/39 patients showed complete cessation and 4/39 patients showed a very good response. No patients of both groups had worsening of seizures. No treatment-limiting adverse events associated with TPM were reported.
Conclusions:
TPM is effective in newly diagnosed patients with FLE; TPM can be considered for the treatment of FLE.
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