Related Experiment Video
Updated: Jul 17, 2026

14:33
Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species
Published on: August 30, 2012
Adolescent disc degeneration--no headache association
K Laimi1, M Erkintalo, L Metsähonkala
1Department of Public Health, University of Turku, Finland. klaimi@utu.fi
Cephalalgia : an International Journal of Headache
|January 11, 2007
Summary
Adolescent headaches are not linked to cervical spine disc degeneration. Mild spinal changes are common in teens but do not cause headaches, according to MRI scans.
Area of Science:
- Neurology
- Radiology
- Adolescent Medicine
Background:
- Headache is a common complaint in adolescents.
- Cervical spine disc degeneration is a potential concern, but its prevalence and association with headache in adolescents are not well understood.
Purpose of the Study:
- To investigate the association between headache and cervical spine disc degeneration in adolescents.
- To compare disc degeneration in adolescents with and without frequent headaches.
Main Methods:
- Population-based follow-up study involving 17-year-old adolescents.
- Magnetic resonance imaging (MRI) of the cervical spine was performed on 47 adolescents with headache and 22 headache-free controls.
- MRI scans were independently reviewed by three neuroradiologists to assess disc degeneration.
Main Results:
- Disc degeneration was observed in 67% of all participants.
- No significant difference in the prevalence of cervical spine disc degeneration was found between adolescents with headache and headache-free controls.
- Degenerative changes were predominantly located in the lower cervical spine.
Conclusions:
- Mild cervical spine disc degeneration is common in adolescents.
- Adolescent headache is not associated with increased cervical spine disc degeneration.
- The presence of mild degenerative changes in the cervical spine does not appear to be a contributing factor to headaches in this age group.
Related Concept Videos
Degenerative Disc Disease I: Introduction
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Degenerative Disc Disease ll: Pathophysiology
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Huntington Disease l: Introduction
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Alzheimer's Disease: Overview
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease ll: Pathophysiology
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
