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Changes in zinc absorption during development.

K Michael Hambidge1, Nancy F Krebs, Jamie E Westcott

  • 1Section of Nutrition, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA. Michael.Hambidge@uchsc.edu

The Journal of Pediatrics
|January 11, 2007
PubMed
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Zinc absorption mechanisms mature early in infants, comparable to adults. However, preterm infants struggle with zinc retention due to high requirements and limited absorption capacity.

Area of Science:

  • Nutritional Science
  • Pediatric Gastroenterology
  • Human Physiology

Background:

  • Zinc (Zn) nutrition is critical for infants and young children.
  • Understanding the maturation and comparative aspects of Zn absorption is limited.
  • Infant Zn absorption efficiency and regulatory mechanisms require further investigation.

Purpose of the Study:

  • To compare zinc absorption in term infants, preterm infants, and adults.
  • To investigate the maturation of zinc absorption mechanisms in early life.
  • To assess zinc homeostasis in relation to absorption and requirements in different infant groups.

Main Methods:

  • Utilized Zn stable isotopes as extrinsic labels over a 24-hour period.
  • Applied saturation kinetic analysis (saturable response model) to existing data.

Related Experiment Videos

  • Adjusted Zn absorption efficiency for differences in small intestinal length.

    • Main Results:

    • Infant Zn absorption efficiency, adjusted for intestinal length, is comparable to adults, indicating early maturation.
    • Infant intestinal length is shorter, leading to a proportionally lower Zn absorptive capacity.
    • Preterm infants exhibit high Zn requirements not met by their absorption and retention capabilities, unlike term infants.

    Conclusions:

    • Mechanisms regulating zinc absorption appear to mature early in human development.
    • While term infants have matched Zn requirements with absorptive capacity, preterm infants face challenges.
    • Preterm infants may experience insufficient Zn absorption and suboptimal endogenous Zn conservation, impacting overall retention.