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Microenvironmental genomic alterations and clinicopathological behavior in head and neck squamous cell carcinoma

Frank Weber1, Yaomin Xu, Li Zhang

  • 1Genomic Medicine Institute and Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

JAMA
|January 11, 2007
PubMed
Abstract

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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Mutations

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