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Angiotensin-(1-7) prevents diabetes-induced cardiovascular dysfunction
Ibrahim F Benter1, Mariam H M Yousif, Constantin Cojocel
1Dept. of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, P. O. Box 24923, Safat 13110, Kuwait. ibenter@hsc.edu.kw
American Journal of Physiology. Heart and Circulatory Physiology
|January 11, 2007
Summary
Treatment with angiotensin-(1-7) [ANG-(1-7)] or its analog AVE-0991 protected against diabetes-induced cardiovascular dysfunction. These findings suggest a potential therapeutic strategy for diabetic patients to reduce cardiovascular events.
Area of Science:
- Cardiovascular Science
- Endocrinology
- Pharmacology
Background:
- Diabetes mellitus is associated with significant cardiovascular complications.
- Diabetic cardiovascular dysfunction involves alterations in vascular responsiveness and cardiac function.
- The renin-angiotensin system plays a critical role in cardiovascular regulation.
Purpose of the Study:
- To investigate the protective effects of angiotensin-(1-7) [ANG-(1-7)] and its nonpeptide analog AVE-0991 against diabetes-induced cardiovascular dysfunction.
- To assess the impact of ANG-(1-7) and AVE-0991 on proteinuria, vascular reactivity, and cardiac recovery from ischemia-reperfusion in a diabetic rat model.
Main Methods:
- Streptozotocin-induced diabetic rats were treated with ANG-(1-7) or AVE-0991 for 4 weeks.
- Evaluated proteinuria, vascular responsiveness to vasoactive agonists in isolated arteries and mesenteric beds.
- Assessed cardiac recovery from ischemia-reperfusion in isolated perfused hearts.
Main Results:
- Diabetes significantly increased proteinuria, which was reduced by ANG-(1-7) and AVE-0991 treatment.
- Both treatments prevented diabetes-induced abnormal vascular responsiveness to various agonists.
- Cardiac function recovery from ischemia-reperfusion was significantly improved in treated diabetic rats.
Conclusions:
- Activation of angiotensin-(1-7) [ANG-(1-7)]-mediated pathways confers protection against diabetes-induced cardiovascular dysfunction.
- ANG-(1-7) and AVE-0991 demonstrate therapeutic potential for mitigating cardiovascular complications in diabetes.
- Targeting ANG-(1-7) signaling represents a promising strategy for managing cardiovascular events in diabetic patients.
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