Vitamin D, insulin resistance, and renal disease

Chonchol and Scragg report the results of a population study on levels of 25-hydroxyvitamin D in patients with renal dysfunction. They demonstrate that these patients do not show vitamin D deficiency unless renal function is severely affected (GFR<29 mL/min/1.73m2), while vitamin D and renal function loss are independently associated with insulin resistance. These data provide more solid evidence than previous available studies on small patient groups, and pose new questions about the mechanisms responsible for progressive renal disease as well as potential effects of vitamin D supplementation.