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Published on: May 16, 2019
Vigabatrin-attributable visual field defects in patients with intractable partial epilepsy.
Yu-Lung Tseng1, Min-Yu Lan, Shung-Lon Lai
1Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Acta Neurologica Taiwanica
|January 12, 2007
Summary
Vigabatrin (VGB) causes visual field defects in most patients. This study found a high prevalence of these defects, but no specific risk factors were identified, highlighting the need for regular eye exams.
Area of Science:
- Ophthalmology
- Neurology
- Pharmacology
Background:
- Vigabatrin (VGB) is associated with visual field defects.
- Estimating the prevalence and characterizing VGB-attributable visual field defects is crucial.
Purpose of the Study:
- To estimate the prevalence of visual field defects in patients treated with Vigabatrin (VGB).
- To describe the characteristics of these visual field defects.
- To investigate potential risk factors for VGB-attributable visual field defects.
Main Methods:
- Static perimetric examinations were conducted on patients with intractable partial epilepsy receiving VGB add-on treatment.
- Visual field charts were analyzed using a three-grade system.
- Clinical features and treatment courses were examined for risk factors.
Main Results:
- Visual field defects were detected in 79% of patients (27/34).
- Bilateral defects occurred in 59% of those with both eyes tested (16/27), with seven showing severe, nasally dominant, or concentric patterns.
- No significant risk factors (e.g., VGB dosage, epilepsy duration) were identified.
Conclusions:
- A high prevalence of Vigabatrin (VGB)-related visual field defects exists.
- No identifiable risk factors were found in this study.
- Routine and regular visual field examinations, particularly within 60 degrees of fixation, are recommended for patients on VGB.
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