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Related Experiment Video

Updated: Jul 17, 2026

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Published on: November 2, 2014

Ovarian cancer screening.

M Kyrgiou¹, I Tsoumpou, P Martin-Hirsch

¹Department of Obstetrics and Gynaecology, Hammersmith Hospital, Queen Charlotte's and Chelsea Hospital, London, W12 OHS.

Anticancer Research

|January 12, 2007

Summary

Current ovarian cancer screening (OCS) methods show promise, with a multimodal approach (CA125 and ultrasound) appearing most effective. However, evidence to support widespread screening based on reduced mortality is still lacking.

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Area of Science:

Gynecologic Oncology
Preventive Medicine
Diagnostic Accuracy

Background:

Ovarian cancer remains a significant health concern with challenges in early detection.
Screening aims to identify ovarian cancer at earlier, more treatable stages.
Evaluating the effectiveness of various ovarian cancer screening (OCS) strategies is crucial.

Purpose of the Study:

To review current knowledge on ovarian cancer screening (OCS).
To cumulatively evaluate the efficacy of diverse OCS approaches.
To present up-to-date results on screening effectiveness.

Main Methods:

Conducted an electronic literature search.
Focused on reports detailing the effectiveness of different screening strategies.
Included prospective studies, cohorts, and randomized control trials (RCTs).

Main Results:

Retrieved 22 prospective studies, 18 cohorts, and 4 RCTs.
Reported sensitivity, specificity, and predictive values where available.
Calculated the number needed to treat (NNT) for each cancer and stage I disease (NNT(I)).

Conclusions:

A multimodal approach using CA125 (primary) and ultrasound (secondary) appears superior.
A reduction in mortality is the definitive endpoint for justifying screening introduction.
Currently, insufficient evidence exists to support the widespread implementation of OCS.