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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Expression of vascular endothelial growth factor in malignant mesothelioma

Keisuke Aoe1, Akio Hiraki, Takehiro Tanaka

  • 1Department of Medical Oncology, NHO Sanyo National Hospital, Yamaguchi, Japan. keisukeaoe@mtf.biglobe.ne.jp

Anticancer Research
|January 12, 2007
PubMed

Insights

Vascular endothelial growth factor (VEGF) is highly expressed in most malignant mesothelioma tumors, particularly the epithelioid type. However, VEGF expression did not correlate with patient survival or other clinicopathological factors in this study.

Area of Science:

  • Oncology
  • Pathology
  • Molecular Biology

Background:

  • Malignant mesothelioma is a primary pleural neoplasm.
  • Angiogenesis, crucial for tumor growth and metastasis, is often driven by vascular endothelial growth factor (VEGF).
  • VEGF is a potent mitogen for endothelial cells.

Purpose of the Study:

  • To investigate the relationship between VEGF expression and clinicopathological variables in malignant mesothelioma.
  • To determine if VEGF expression is associated with overall survival in patients with malignant mesothelioma.

Main Methods:

  • Analysis of VEGF expression in 37 malignant pleural mesothelioma samples.
  • Correlation of VEGF expression with histological type, gender, age, and clinical stage.
  • Assessment of VEGF expression's impact on patient survival.

Main Results:

  • 97.3% of malignant mesothelioma samples showed positive VEGF staining.
  • Increased VEGF expression was observed in epithelioid mesothelioma compared to biphasic and sarcomatoid types.
  • No significant association was found between VEGF expression and gender, age, clinical stage, or overall survival.

Conclusions:

  • VEGF is widely expressed in malignant mesothelioma, with higher levels in the epithelioid subtype.
  • VEGF expression is not a prognostic factor for survival in malignant mesothelioma patients.
  • While important for tumor development, VEGF's role as a prognostic marker in this cancer requires further investigation.

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