Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum levels of tumor necrosis factor-like cytokine 1A and its receptors, death receptor 3 and decoy receptor 3, in patients with spondyloarthropathies: preliminary results from a cross-sectional study.

Reumatologia·2025
Same author

Prevalence and clinical associations of antinuclear antibodies (ANA) in spondyloarthropathies.

Advances in medical sciences·2025
Same author

Lung function and skin fibrosis changes as predictors of survival in SSc-associated interstitial lung disease: a EUSTAR study.

Rheumatology (Oxford, England)·2025
Same author

Is there a link between choroidal and retinal parameters in patients with systemic sclerosis? A prospective study.

Photodiagnosis and photodynamic therapy·2025
Same author

A phase 2 randomized trial of safety and pharmacokinetics of IgPro20 and IgPro10 in patients with diffuse cutaneous systemic sclerosis.

Rheumatology (Oxford, England)·2025
Same author

Assessment of interocular symmetry of choroidal vascularity index and thickness in patients with systemic sclerosis: a prospective study.

Frontiers in medicine·2025

Related Experiment Video

Updated: Jul 17, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Targeting vascular disease in systemic sclerosis.

Otylia Kowal-Bielecka1

  • 1Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Ul. M. Curie-Sklodowskiej 24 A, 15-276 Bialystok, Poland. otylia@amb.edu.pl

Endocrine, Metabolic & Immune Disorders Drug Targets
|January 12, 2007
PubMed
Summary

Systemic sclerosis (SSc), or scleroderma, involves fibrosis and vascular injury. Treatments targeting vascular aspects show promise for managing this complex autoimmune disease.

More Related Videos

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases
04:59

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Published on: June 20, 2025

Related Experiment Videos

Last Updated: Jul 17, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases
04:59

Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases

Published on: June 20, 2025

Area of Science:

  • Rheumatology
  • Immunology
  • Vascular Medicine

Background:

  • Systemic sclerosis (SSc), also known as scleroderma, is a chronic autoimmune disease.
  • It is characterized by excessive fibrosis, vascular injury, autoimmunity, and inflammation.
  • These features lead to irreversible organ damage, significant morbidity, and mortality in patients.

Purpose of the Study:

  • To review recent and potential future treatments for SSc-associated vascular disease.
  • To highlight the success of therapies targeting vascular aspects of SSc.
  • To underscore the importance of vascular injury in SSc pathogenesis.

Main Methods:

  • Literature review of recent advancements in SSc treatment.
  • Analysis of therapeutic strategies focusing on vascular manifestations.
  • Synthesis of current understanding of SSc pathogenesis.

Main Results:

  • Therapies targeting vascular aspects of SSc have demonstrated the most success to date.
  • Progress in understanding SSc pathogenesis enables more effective treatment strategies.
  • Vascular injury plays a critical role in the development and progression of SSc.

Conclusions:

  • Targeting vascular aspects offers significant hope for improved SSc patient management.
  • Further research into SSc-associated vascular disease is crucial.
  • Advances in understanding and treating SSc are leading to better outcomes.