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Related Experiment Video

Updated: Jul 17, 2026

Histological Quantification of Chronic Myocardial Infarct in Rats
09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

Infarct size assessment in mice.

Marielle Scherrer-Crosbie1, Ana Clara T Rodrigues, Ryuji Hataishi

  • 1Cardiac Ultrasound Laboratory, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. marielle@crosbie.com

Echocardiography (Mount Kisco, N.Y.)
|January 12, 2007
PubMed
Summary

This review covers mouse models of myocardial infarction (MI) and ischemia reperfusion (I/R). It details surgical methods and uses echocardiography to assess cardiac damage and perfusion in these critical cardiovascular research models.

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Area of Science:

  • Cardiovascular Research
  • Animal Models
  • Medical Imaging

Background:

  • Genetically modified mice are crucial for studying myocardial infarction (MI) and ischemia reperfusion (I/R) injury.
  • Understanding these pathologies requires precise methods to assess cardiac damage.
  • Echocardiography offers a noninvasive approach for serial monitoring of cardiac function in murine models.

Purpose of the Study:

  • To review surgical techniques for creating I/R and MI models in mice.
  • To outline pathological methods for measuring infarct size.
  • To highlight echocardiographic techniques for assessing murine area at risk and MI size.

Main Methods:

  • Detailed description of surgical procedures for inducing I/R and MI in mice.
  • Pathological assessment of myocardial infarct size.

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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Related Experiment Videos

Last Updated: Jul 17, 2026

Histological Quantification of Chronic Myocardial Infarct in Rats
09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

  • Application of echocardiography, including wall motion analysis.
  • Utilizing myocardial contrast echocardiography to evaluate perfusion defects.

    • Main Results:

    • Surgical models provide reproducible methods for studying cardiac I/R and MI.
    • Pathology offers quantitative measurement of infarct size.
    • Echocardiography enables serial, noninvasive assessment of cardiac phenotype and injury extent.

    Conclusions:

    • Integrated pathological and echocardiographic assessments are vital for accurate evaluation of murine I/R and MI models.
    • These methods enhance the understanding of cardiovascular disease mechanisms in research settings.
    • Echocardiography is a powerful tool for longitudinal monitoring in cardiac murine studies.