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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Compromised GCF total antioxidant capacity in periodontitis: cause or effect?
I L C Chapple1, G R Brock, M R Milward
1Periodontal Research Group, School of Dentistry, University of Birmingham, Birmingham B4 6NN, UK. I.L.C.Chapple@bham.ac.uk
Journal of Clinical Periodontology
|January 12, 2007
Summary
Total antioxidant capacity (TAOC) in gingival crevicular fluid (GCF) is reduced in periodontitis patients. Successful non-surgical therapy restores GCF TAOC to healthy levels, indicating it reflects local inflammation.
Area of Science:
- Periodontology
- Biochemistry
- Oxidative Stress Research
Background:
- Periodontitis pathogenesis involves oxidative stress.
- Total antioxidant capacity (TAOC) in gingival crevicular fluid (GCF) and plasma is altered in periodontitis.
- The role of TAOC changes in periodontitis progression is unclear.
Purpose of the Study:
- To examine longitudinal changes in GCF and plasma TAOC after non-surgical periodontal therapy.
- To assess the impact of reduced periodontal inflammation on antioxidant capacity.
Main Methods:
- Two longitudinal studies involving non-smokers with chronic periodontitis (CP).
- GCF and plasma TAOC measured at baseline and 3 months post-therapy using enhanced chemiluminescence.
- Comparison with periodontally healthy controls.
Main Results:
- No significant difference in plasma TAOC between CP patients and controls at baseline or post-therapy.
- GCF TAOC was significantly lower in CP patients compared to controls at baseline.
- Successful therapy increased GCF TAOC, restoring it to levels observed in healthy individuals.
Conclusions:
- Local TAOC in CP reflects increased oxygen radical activity during inflammation.
- Non-surgical periodontal therapy effectively restores GCF TAOC to normal levels.
- GCF TAOC serves as a potential biomarker for periodontal inflammation and treatment response.
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