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Insulin-like growth factor-1, leptin, body composition, and clinical status interactions in children with cystic

Margaret C S Boguszewski1, Tsukiyo Obu Kamoi, Rosana Bento Radominski

  • 1Pediatric Endocrinology Unit, Department of Pediatrics, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil. margabogus@bol.com.br

Hormone Research
|January 12, 2007
PubMed

Insights

Children with cystic fibrosis (CF) have lower fat and lean body mass, with decreased serum insulin-like growth factor-1 (IGF-1) and leptin levels. These markers are linked to disease activity and body composition in CF patients.

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Science
  • Cystic Fibrosis Research

Background:

  • Children with cystic fibrosis (CF) face increased risks of reduced fat body mass (FBM) and lean body mass (LBM).
  • Serum concentrations of insulin-like growth factor-1 (IGF-1) and leptin may indicate depletion of LBM and/or FBM.

Purpose of the Study:

  • To evaluate the relationships between disease activity, body composition, and IGF-1 and leptin concentrations in children with CF.

Main Methods:

  • A cross-sectional study involving 26 children with CF (aged 5.0-15.5 years) and 33 healthy controls.
  • Body composition was assessed using dual-energy X-ray absorptiometry.
  • Fasting blood samples were analyzed for leptin, IGF-1, and IGFBP-3.

Main Results:

  • CF children exhibited lower FBM, leptin concentrations, and IGF-1 standard deviation scores (SDS) compared to controls.
  • The Shwachman score was the strongest predictor of LBM (R = 0.63).
  • Leptin levels accounted for 60% of the variability in FBM.

Conclusions:

  • Serum concentrations of IGF-1 and leptin are decreased in children with CF.
  • These hormonal changes are associated with clinical conditions and altered body composition in pediatric CF patients.
Abstract

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