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[Aging and exocrine pancreatic function evaluated by the recently standardized secretin test]
T Ishibashi1, S Matsumoto, H Harada
1Second Department of Internal Medicine, Okayama University Medical School.
Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|September 1, 1991
Summary
Aging significantly impairs exocrine pancreatic function, particularly secretory volume and bicarbonate output after age 50. Enzyme output also declines with age, indicating a general reduction in pancreatic exocrine capacity over time.
Area of Science:
- Gastroenterology
- Aging Research
- Pancreatic Physiology
Background:
- Exocrine pancreatic function is crucial for digestion.
- The impact of aging on pancreatic function requires further elucidation.
- Standardized secretin tests offer a reliable method for assessment.
Purpose of the Study:
- To investigate the relationship between aging and exocrine pancreatic function.
- To evaluate changes in pancreatic secretory volume, bicarbonate, and enzyme output with age.
Main Methods:
- Utilized a standardized secretin test to collect pancreatic juice.
- Assessed secretory volume, maximal bicarbonate concentration, and enzyme output (amylase, lipase).
- Compared function across age groups: <40, 40-65, and ≥65 years.
Main Results:
- Older adults (≥65 years) exhibited significantly lower secretory volume, bicarbonate output, and enzyme output compared to younger groups.
- Enzyme output showed a consistent decrease with advancing age.
- Secretory volume and bicarbonate output peaked around age 40, declining sharply after the late 50s, with a more pronounced decrease than enzyme output in older individuals.
Conclusions:
- Aging is associated with a significant decline in exocrine pancreatic function.
- Secretory volume and bicarbonate output are particularly affected by aging, especially after age 50.
- These findings highlight age-related changes in pancreatic exocrine capacity.