Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Carbidopa/levodopa-responsive myoclonus.

David B Fitzgerald¹, Valeria Drago, Dean Sutherland

¹Brain Rehabilitation Research Center, Malcom Randall VAMC, Gainesville, Florida, USA. dfitzger@massmed.org

Movement Disorders : Official Journal of the Movement Disorder Society

|January 12, 2007

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

People with disabilities and Meta Humans: A review-based research note for transformative service researchers.

Health marketing quarterly·2026

Same author

Real-World Response and Super-Response to Eptinezumab over 48 Weeks in Migraine: The Prospective Multicenter EMBRACE III Study.

Neurology and therapy·2026

Same author

Reflecting on Themes From Telehealth Consultations Early in the Pandemic: An Opportunity to Learn From Multiprofessional Colleagues.

International journal of telemedicine and applications·2026

Same author

Positive Response to Rehabilitation Initiated 18 Months after Penetrating Cranial Injury with Screwdriver Involving Temporal Lobe and Brainstem.

American journal of physical medicine & rehabilitation·2026

Same author

Responders and super-responders to atogepant after 24 weeks of treatment in migraine: real-world evidence from the GIANT-2 study.

The journal of headache and pain·2026

Same author

Case Reports and Case Studies: An Endangered Species.

Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology·2025

A patient with parkinsonism experienced involuntary jerking movements (myoclonus) that significantly improved with carbidopa/levodopa treatment. The exact reason for this positive response remains unclear.

Area of Science:

Neurology
Movement Disorders
Pharmacology

Background:

Myoclonus is a neurological disorder characterized by sudden, involuntary muscle jerks.
Parkinsonism encompasses a group of neurological conditions affecting movement, often including tremors and rigidity.

Observation:

A 64-year-old woman presented with progressive myoclonus affecting her right arm, hand, and trunk.
The patient exhibited clinical features suggestive of parkinsonism.

Findings:

Treatment with carbidopa/levodopa, a common therapy for Parkinson's disease, resulted in a dramatic improvement of her myoclonus.
This suggests a potential link between dopaminergic pathways and the observed myoclonus.

Implications:

Related Experiment Videos

The findings suggest that dopaminergic dysfunction may play a role in certain types of myoclonus, particularly in patients with parkinsonian features.

Further research is warranted to elucidate the precise neurobiological mechanisms underlying this carbidopa/levodopa-responsive myoclonus.