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Updated: Jul 17, 2026
08:29
SUMO-Binding Entities (SUBEs) as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
Published on: November 1, 2019
SUMO, the three Rs and cancer
J S Seeler1, O Bischof, K Nacerddine
1Nuclear Organisation and Oncogenesis Unit, INSERM U.579, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris 15, France. seeler@pasteur.fr
Current Topics in Microbiology and Immunology
|January 16, 2007
Summary
SUMO modification, or sumoylation, is crucial for DNA repair and genomic integrity. This review highlights sumoylation
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- SUMO modification (sumoylation) is a vital post-translational modification.
- It regulates key cellular processes including nucleo-cytoplasmic transport, gene expression, and DNA metabolism.
Purpose of the Study:
- To review recent evidence on the role of SUMO in maintaining genomic integrity.
- To discuss the involvement of sumoylation and specific SUMO targets in cancer.
Main Methods:
- Literature review of recent scientific evidence.
- Analysis of studies focusing on SUMO's role at chromosomal and DNA levels.
- Discussion of cancer-related research involving sumoylation.
Main Results:
- SUMO plays a significant role in protecting genomic integrity.
- Evidence supports SUMO's function in both chromosomal stability and DNA repair mechanisms.
- Specific SUMO targets and their dysregulation are implicated in cancer development.
Conclusions:
- Sumoylation is essential for safeguarding the genome.
- Understanding SUMO's role in genomic maintenance offers insights into cancer biology.
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