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Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Repressible Operon: trp Operon01:21

Repressible Operon: trp Operon

The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...
Cotranslational Protein Translocation01:20

Cotranslational Protein Translocation

Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
Sec61 channel partners for cotranslational translocation
During cotranslational translocation, the Sec61 channel partners with the signal recognition particle (SRP), the signal recognition particle receptor (SR), and the ribosomes to transport the nascent polypeptide chain...
LTR Retrotransposons03:08

LTR Retrotransposons

LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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Articles linked to this work by shared authors, journal, and citation graph.

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Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001
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Insect mechanoreception: what a long, strange TRP it's been.

Current biology : CB·2000
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The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations.

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BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.

Proceedings of the National Academy of Sciences of the United States of America·1997
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Related Experiment Video

Updated: Jul 17, 2026

Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3
07:26

Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3

Published on: August 17, 2011

TRPA1.

J García-Añoveros1, K Nagata

  • 1Department of Anesthesiology, Northwestern University Institute for Neuroscience, Feinberg School of Medicine, Ward 10-070, 303 E Chicago Ave., Chicago, IL 60611, USA. anoveros@northwestern.edu

Handbook of Experimental Pharmacology
|January 16, 2007
PubMed
Summary

The Transient Receptor Potential Ankyrin 1 (TRPA1) protein is found in sensory neurons and mediates responses to irritants. Its conserved nature suggests an ancient role in sensation across the animal kingdom.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Sensory Transduction

Background:

  • The Transient Receptor Potential Ankyrin 1 (TRPA1) protein possesses characteristic TRP channel domains.
  • TRPA1 is predominantly expressed in mouse nociceptive neurons and inner ear mechanosensory epithelia.

Purpose of the Study:

  • To discuss the channel properties of TRPA1.
  • To compare TRPA1 to other sensory transducers.
  • To explore the evolutionary conservation and ancestral role of TRPA1.

Main Methods:

  • Analysis of protein structure and domain organization.
  • Review of expression patterns in mice.
  • Comparison of channel properties with known sensory transducers.

Main Results:

More Related Videos

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Related Experiment Videos

Last Updated: Jul 17, 2026

Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3
07:26

Cell-based Calcium Assay for Medium to High Throughput Screening of TRP Channel Functions using FlexStation 3

Published on: August 17, 2011

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

  • TRPA1 exhibits ankyrin repeats and canonical TRP channel domains.
  • TRPA1 mediates responses to bradykinin and pungent irritants like mustard, garlic, cinnamon, and tear gas.
  • TRPA1 shows significant conservation across diverse animal species, from humans to nematodes.

Conclusions:

  • TRPA1 plays a crucial role in nociception and response to environmental irritants.
  • The evolutionary conservation of TRPA1 suggests a fundamental, ancestral function in sensation.