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Updated: Jul 17, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Combined thrombophilic mutations in women with unexplained recurrent miscarriage
Alexandros Sotiriadis1, George Vartholomatos, Matthaios Pavlou
1Department of Obstetrics and Gynecology, University Hospital of Ioannina, Ioannina, Greece. asotir@gmail.com
Problem:
To compare the prevalence of five common thrombophilic polymorphisms and their combination in women with recurrent miscarriage and a control group.
Method Of Study:
Genomic analysis using polymerase chain reaction (PCR) was carried out in patients with two or more miscarriages and controls for Factor V Leiden, Factor V A1299H (HR2), Factor II G20210A, MTHFR C677T and MTHFR A1298C. Secondary analyses were made for number of miscarriages and gestational age at miscarriage.
Results:
None the mutations was associated with significantly increased risk for recurrent miscarriage. The prevalence of combined thrombophilias (4/88 versus 2/88) did not increase the risk for miscarriage (OR 2.04, 95% CI 0.36-11.47). Although virtually all patients with thrombophilia had miscarriages
Conclusions:
Combinations of the five thrombophilic mutations studied are an uncommon event with heterogeneous pattern and they do not significantly increase the risk for miscarriage.
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