Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholinergic grafts, memory and ageing.

S Dunnett1

  • 1Dept of Experimental Psychology, University of Cambridge, UK.

Trends in Neurosciences
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

Neural grafts successfully integrated into rat brains, improving cognitive function after injury or aging. However, this approach is unlikely to treat human dementia due to the widespread neuronal loss involved.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preface.

Progress in brain research·2017
Same author

Preface.

Progress in brain research·2017
Same author

Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY.

Journal of neurology, neurosurgery, and psychiatry·2010
Same author

Transplanted dopaminergic neurons: more or less?

Nature medicine·2001
Same author

Ivan Divac and the neostriatum as a cognitive structure.

Brain research bulletin·2000
Same author

Immunohistochemical identification of rat adrenal cortical tissue in situ, in vitro, and in intracerebral adrenal grafts.

Experimental neurology·1993

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Neurobiology

Background:

  • Cholinergic systems are crucial for cognitive functions like memory.
  • Degeneration of cholinergic neurons is implicated in aging and dementia.
  • Neural transplantation is a potential strategy for neuronal repair.

Purpose of the Study:

  • To investigate the survival and functional capacity of cholinergic neural grafts in rat brains.
  • To explore the potential of neural transplantation for ameliorating cognitive deficits.
  • To understand the role of forebrain cholinergic systems in cognition and aging.

Main Methods:

  • Transplantation of cholinergic-rich neural grafts into the rat neocortex and hippocampus.
  • Assessment of graft survival and integration.

Related Experiment Videos

  • Evaluation of functional recovery in lesioned or aged rats.

    • Main Results:

    • Cholinergic neural grafts survived transplantation to the rat neocortex and hippocampus.
    • Grafts ameliorated functional deficits associated with lesions and natural aging.
    • The technique provided insights into cholinergic system function and degeneration.

    Conclusions:

    • Neural grafts can functionally restore deficits related to cholinergic system damage in rats.
    • This model enhances understanding of cholinergic involvement in memory and aging.
    • Neural transplantation is unlikely to be a viable therapy for human dementia due to disease complexity.