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Glycosylated haemoglobin levels in children with protein-energy malnutrition

S A Adegbenro1, O A Dada, D M Olanrewaju

  • 1Department of Pathology, College of Health Sciences, Ogun State University Teaching Hospital, Sagamu, Nigeria.

Annals of Tropical Paediatrics
|January 1, 1991
PubMed

Insights

Protein-energy malnutrition in young children is linked to higher glycosylated haemoglobin (HbA1c) levels, suggesting glucose intolerance. Long-term monitoring of HbA1c is recommended for these children.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Nutritional Science

Background:

  • Protein-energy malnutrition (PEM) is a significant health concern in children.
  • Altered glucose metabolism may occur in children with PEM.
  • Glycosylated hemoglobin (HbA1c) reflects long-term glycemic control.

Purpose of the Study:

  • To investigate glycemic status in children with PEM.
  • To compare HbA1c levels in children with PEM versus healthy controls.
  • To explore the relationship between blood glucose and HbA1c in malnourished children.

Main Methods:

  • Measured fasting blood glucose, serum protein, and HbA1c.
  • Included 50 children (1-5 years) with PEM and 25 healthy controls.
  • Statistical analysis to compare groups and assess correlations.

Main Results:

  • Children with PEM showed significantly higher HbA1c levels than controls.
  • HbA1c levels correlated well with blood glucose values.
  • Elevated HbA1c indicates glucose intolerance in children with PEM.

Conclusions:

  • Children with PEM exhibit glucose intolerance.
  • Long-term glycemic monitoring using HbA1c is valuable.
  • Further research may clarify the link between HbA1c and pancreatic function in PEM.

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