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Updated: Jul 12, 2026

Nuclear Magnetic Resonance Spectroscopy for the Identification of Multiple Phosphorylations of Intrinsically Disordered Proteins
Published on: December 27, 2016
Ex situ NMR in highly homogeneous fields: 1H spectroscopy
Juan Perlo1, Federico Casanova, Bernhard Blümich
1Institut für Technische Chemie und Makromolekulare Chemie, Rheinisch-Westfälische Technische Hochschule-Aachen, D-52056, Germany.
Abstract:
Portable single-sided nuclear magnetic resonance (NMR) magnets used for nondestructive studies of large samples are believed to generate inherently inhomogeneous magnetic fields. We demonstrated experimentally that the field of an open magnet can be shimmed to high homogeneity in a large volume external to the sensor. This technique allowed us to measure localized high-resolution proton spectra outside a portable open magnet with a spectral resolution of 0.25 part per million. The generation of these experimental conditions also simplifies the implementation of such powerful methodologies as multidimensional NMR spectroscopy and imaging.
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