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Comment on "A common genetic variant is associated with adult and childhood obesity"
Christian Dina1, David Meyre, Chantal Samson
1CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France. dina@good.ibl.fr
Abstract:
Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.
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