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Related Experiment Videos

Strenuous exercise: analogous to the acute-phase response?

L M Weight1, D Alexander, P Jacobs

  • 1University of Cape Town Leukemia Center, South Africa.

Clinical Science (London, England : 1979)
|November 1, 1991
PubMed
Summary
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Strenuous exercise triggers changes in athletes similar to the acute-phase response, involving elevated inflammatory markers and cortisol. Interleukin-1 appears crucial in mediating these hematological and immunological shifts post-marathon.

Area of Science:

  • Exercise Physiology
  • Immunology
  • Sports Medicine

Background:

  • The physiological impact of strenuous exercise is often compared to the acute-phase response.
  • Understanding these responses is key to athlete recovery and performance.

Purpose of the Study:

  • To investigate the physiological and immunological changes in marathon runners post-exercise.
  • To determine if exercise-induced changes mimic the acute-phase response.
  • To explore the role of interleukin-1 in these adaptations.

Main Methods:

  • Blood samples were collected from 90 competitive distance runners (70 male, 20 female) immediately, 24, and 48 hours after a marathon.
  • Analyzed parameters included neutrophil count, plasma cortisol, creatine kinase, C-reactive protein, total protein, albumin, fibrinogen, haptoglobin, and interleukin-1 activity.

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  • Iron status markers were also assessed.

    • Main Results:

    • Transient neutrophil leukocytosis and increased plasma cortisol, creatine kinase, C-reactive protein, total protein, and albumin were observed immediately post-marathon.
    • Elevated plasma fibrinogen, C-reactive protein, and total protein persisted at 24 and 48 hours.
    • Increased interleukin-1 activity was noted immediately and 24 hours post-exercise, while serum haptoglobin decreased and then recovered.

    Conclusions:

    • Sustained strenuous exercise induces metabolic and immunological changes similar, but not identical, to the acute-phase response.
    • Interleukin-1 likely plays a significant role in the observed hematological and immunological alterations following endurance events.
    • These findings provide insights into the body's complex response to extreme physical exertion.