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Updated: Jul 17, 2026

Detection and Isolation of Apoptotic Bodies to High Purity
Published on: August 12, 2018
[Apoptosis and its role in plastic surgery]
Abstract:
Apoptosis and cell proliferation are the main mechanisms of cell homeostasis. The pathogenesis of approximately 70 % of all diseases results from an imbalance between these two counterparts. Therefore, research on apoptosis is a main target in biological and clinical fields. Many signalling pathways and proteins involved in their regulation have been characterized. In order to evaluate the relevance of apoptosis in plastic surgery, the literature was reviewed for its impact on ischemia and reperfusion concerning flap surgery as well as wound healing and angiogenesis. Furthermore, the relevance of apoptosis in ageing, allotransplantation and tumors was investigated. In all subsections of plastic surgery, a high impact was identified. More studies on the influence and regulation of apoptosis can bring further understanding on the disease patterns of plastic surgery and other specialties as well as the development of new therapeutic options. Research focusing on apoptosis is therefore an essential means for the advancement of and future trends in plastic surgery.
Insights
Apoptosis, programmed cell death, is crucial for cell balance and disease. Understanding its role in plastic surgery, from wound healing to aging, offers new therapeutic avenues.
Area of Science:
- Cellular Biology
- Homeostasis Mechanisms
- Disease Pathogenesis
Context:
- Apoptosis and cell proliferation are key to cell homeostasis.
- Imbalances contribute to ~70% of diseases.
- Apoptosis research is vital in biological and clinical fields.
Purpose:
- To review the literature on apoptosis's impact in plastic surgery.
- To investigate its relevance in flap surgery, wound healing, angiogenesis, aging, allotransplantation, and tumors.
Summary:
- A literature review evaluated apoptosis's role in plastic surgery subfields.
- High impact identified across flap surgery, wound healing, aging, allotransplantation, and tumors.
- Apoptosis regulation is key to understanding disease and developing therapies.
Impact:
- Further research can elucidate disease patterns in plastic surgery and other specialties.
- Enhanced understanding may lead to novel therapeutic strategies.
- Apoptosis research is essential for advancing plastic surgery.
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