Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DepMatch: Boosting Semi-Supervised Semantic Segmentation by Exploring Depth Difference Knowledge.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Societyยท2026
Same author

Collaborated With Hallucination: Enhancing Egocentric Grounded Question Answering via Error Demonstrations.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Societyยท2026
Same author

Generalizable Egocentric Task Verification via Cross-Modal Hybrid Hypergraph Matching.

IEEE transactions on pattern analysis and machine intelligenceยท2026
Same author

Jo-SNC: Combating Noisy Labels Through Fostering Self- and Neighbor-Consistency.

IEEE transactions on pattern analysis and machine intelligenceยท2025
Same author

Profiling Associations Between IGHG-FCGR Ligand-Receptor Interactions and Disease Progression From Stage 1 and 2 to Stage 3 Type 1 Diabetes.

Diabetesยท2025
Same author

Correction: Profiling associations of interactive ligand-receptors (HLA class I and KIR gene products) with the progression to type 1 diabetes among seroconverted participants.

Diabetologiaยท2025

Related Experiment Video

Updated: Jul 17, 2026

Infinium Assay for Large-scale SNP Genotyping Applications
13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

A haplotype-linkage analysis method for estimating recombination rates using dense SNP trio data.

Lue Ping Zhao1, Shuying Sue Li, Fumin Shen

  • 1Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. lzhao@fhcrc.org

Genetic Epidemiology
|January 16, 2007
PubMed
Summary

This study introduces the haplotype-linkage (HALIN) method to accurately identify meiotic recombination hot spots. HALIN improves genome analysis by estimating recombination rates from family genetic data, enhancing our understanding of human genetic diversity.

More Related Videos

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
13:55

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

Related Experiment Videos

Last Updated: Jul 17, 2026

Infinium Assay for Large-scale SNP Genotyping Applications
13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
13:55

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

Area of Science:

  • Genetics
  • Genomics
  • Evolutionary Biology

Background:

  • Meiotic recombination is crucial for shaping human genomes and driving genetic diversity.
  • Recombination hot spots, specific genomic regions with high recombination rates, are increasingly recognized.
  • Accurate identification of these hot spots is essential for understanding genome evolution.

Purpose of the Study:

  • To develop and validate a novel empirical method for estimating recombination rates.
  • To identify meiotic recombination hot spots using unphased genotype data from nuclear families.
  • To compare the performance of the new method against existing approaches.

Main Methods:

  • Developed the haplotype-linkage (HALIN) method, which infers haplotypes and estimates recombination rates simultaneously.
  • Utilized unphased genotypes from parent-child trios to increase informative meioses.
  • Applied HALIN to chromosome 20 genotype data from the HapMap project.

Main Results:

  • HALIN provides unbiased estimates of recombination rates.
  • The method identified 75 recombination hot spots on chromosome 20.
  • 85% of HALIN-identified hot spots overlapped with those found by the McVean et al. (2004) method, with HALIN detecting additional hot spots.

Conclusions:

  • The HALIN method is a robust and effective tool for identifying meiotic recombination hot spots.
  • HALIN demonstrates consistency with existing methods while offering improved sensitivity.
  • This advancement aids in a deeper understanding of human genome structure and evolution.