[Pregnancy complicated with thrombocytopenia]

Evaluation of the influence of the sort of thrombocytopenia and count of platelets on the course of pregnancy, maternal and neonatal outcomes.

Retrospective analysis of 45 women, threatened of thrombocytopenia.

The trial population consisted of 45 women, where the following parameters were evaluated: age of laboring women, gestational age, the mode of delivery, count of platelets, bleeding complications, the need of treatment with steroids and platelets transfusions, as well as the birth weight of newborns, the Apgar score in the 1st minute, thrombocytopenia and bleeding complications in neonates.

There were 27 women with gestational-induced thrombocytopenia and 18 women had immune thrombocytopenia. Moreover 14 had severe and 31--moderate thrombocytopenia. Premature labor (<37 week of pregnancy) were observed more often in patients with severe than in moderate thrombocytopenia (6/14-42,85% vs. 4/31-16,13%; p < 0.05). Lower neonatal body weight (2774.28 +/- 28 vs. 3120.32 +/- 788.22; p < 0.05), Apgar score in the 1st minute (7.42 +/- 3.56 vs. 9.13 +/- 1.56; p < 0.01), as well as neonatal complications (71.42% vs. 28.58; p < 0.01), were also observed more often in severe than in moderate thrombocytopenia group.

The presence of antiplatelet antiobodies were associated with platelets count <50 x 10(3)/MICROL, the necessity of treatment with steroids and platelet infusions to the mother, as well as delivery of neonates with lower Apgar score in the 1st minute and neonatal thrombocytopenia. Severe thrombocytopenia was associated with the necessity of treatment with steroids and platelet infusions, preterm delivery, lower Apgar score in the 1st minute and neonatal thrombocytopenia.