Genetic basis of limited cell proliferation

Knowledge about the changes that occur as cells traverse their replicative lifespans grows apace, as evidenced by the articles in this issue. Controversy over the interpretation of this knowledge continues, however, and is indeed fuelled by new discoveries (e.g., see Cristofalo, 1990; Holliday, 1990; Smith, 1990). This paper makes a brief commentary on the problems of cellular ageing, with particular emphasis on the unfolding picture of the genetic control of ageing and longevity which derives from evolutionary theory (Kirkwood and Rose, 1991). The case is argued for a synthetic view which recognizes that the immediate causes of limited cell proliferation probably involve some form of active genetic control, but that the ultimate reason for cell ageing is found in evolutionary theories which suggest that the ageing process is not actively programmed and that senescence may be due to the accumulation of damage.