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Activity of daptomycin alone and in combination with rifampin and gentamicin against Staphylococcus aureus assessed
Kim Credito1, Gengrong Lin, Peter C Appelbaum
1Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Abstract:
The synergistic effects of daptomycin plus gentamicin or rifampin were tested against 50 Staphylococcus aureus strains, with daptomycin MICs ranging between 0.25 and 8 microg/ml. Daptomycin sub-MICs combined with gentamicin concentrations lower than the MIC yielded synergy in 34 (68%) of the 50 strains. Daptomycin combined with rifampin yielded synergy in one vancomycin-intermediate S. aureus strain only, and virtually all synergy occurred between daptomycin and gentamicin.
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