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The evaluation of markers of prostatic function
H von der Kammer1, K H Scheit, W Weidner
1Max-Planck-Institute for Biophysical Chemistry, Göttingen, FRG.
Urological Research
|January 1, 1991
Summary
Semen analysis revealed reduced glucosidase in epididymitis and prostatic secretory protein of 94 amino acid residues (PSP94) in prostatitis. Other markers like PSA remained unchanged in genital tract inflammation.
Area of Science:
- Urology
- Biochemistry
- Reproductive Medicine
Background:
- Genital tract inflammation can affect seminal fluid composition.
- Prostate-specific secretory proteins and conventional markers are potential indicators of male reproductive health.
Purpose of the Study:
- To investigate the impact of genital tract inflammation on seminal concentrations of PSP94, PSA, PAP, citrate, glucosidase, and fructose.
- To identify potential biomarkers for inflammatory conditions of the male reproductive system.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure PSP94, PSA, and PAP concentrations in semen.
- Conventional markers (citrate, glucosidase, fructose) were also determined.
- Semen samples were collected from patients with various inflammatory conditions and healthy controls.
Main Results:
- Significant reductions in glucosidase were observed in patients with epididymitis.
- Significant reductions in prostatic secretory protein of 94 amino acid residues (PSP94) were found in patients with prostatitis.
- No significant changes were detected in PSA, PAP, citrate, or fructose levels in semen from patients with genital tract inflammation.
Conclusions:
- Glucosidase and PSP94 may serve as potential biomarkers for specific inflammatory conditions like epididymitis and prostatitis, respectively.
- PSA, PAP, citrate, and fructose are not reliable indicators of genital tract inflammation in this patient cohort.
- Further research is warranted to explore the diagnostic and prognostic value of PSP94 and glucosidase in male reproductive tract infections.