Related Experiment Video
Updated: Jul 17, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
Published on: January 12, 2017
Diabetes and its effects on dental pulp
Orlando Catanzaro1, Damian Dziubecki, Lorena Calvo Lauria
1Medical School and School of Dentistry, University Del Salvador, Buenos Aires, Argentina. ocatan50@aol.com
Poorly controlled diabetes mellitus significantly impacts dental pulp, increasing inflammatory mediators and decreasing collagen. This progression affects oral tissue health, highlighting diabetes as a critical factor in oral complications.
Area of Science:
- Oral Biology
- Endocrinology
- Pathology
Background:
- Diabetes mellitus is linked to various oral health complications.
- Understanding the specific effects of diabetes on dental pulp is crucial for comprehensive patient care.
Purpose of the Study:
- To investigate the impact of diabetes mellitus progression on inflammatory and structural aspects of dental pulp.
- To assess changes in key biochemical markers within the dental pulp over time following diabetes induction.
Main Methods:
- Diabetes was induced in male Wistar rats using Streptozotocin (STZ).
- Dental pulp tissues from incisors and molars were analyzed 30 and 90 days post-STZ injection.
- Measurements included plasma glucose, nitrite, kallikrein, myeloperoxidase, alkaline phosphatase, and collagen concentration.
Main Results:
- Diabetic rats exhibited significantly elevated plasma glucose levels.
- Increased nitrite and kallikrein levels were observed at 30 days post-STZ, with nitrite decreasing by 90 days.
- Myeloperoxidase and alkaline phosphatase activities showed alterations, while collagen concentration decreased significantly in diabetic rats at both time points.
Conclusions:
- Diabetes mellitus significantly affects dental pulp by altering inflammatory mediator expression and structural components.
- Progressive diabetes leads to notable changes in dental pulp, including reduced collagen and modified enzyme activities.
- These findings underscore the critical role of diabetes in the pathogenesis of oral tissue complications.
More Related Videos
14:52Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
Published on: November 24, 2012
05:16Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
Published on: October 27, 2023
Related Concept Videos
Diabetic Neuropathy
Diabetes: Symptoms, Diagnosis, and Complications
Tooth Anatomy
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Diabetes Mellitus: Type 2 and Gestational
Complications of Diabetes Mellitus
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...