Related Experiment Video
Updated: Jul 17, 2026

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
Published on: December 8, 2017
Systemic infections and inflammation affect chronic neurodegeneration
V Hugh Perry1, Colm Cunningham, Clive Holmes
1Southampton Neuroscience Group, School of Biological Sciences and School of Medicine, University of Southampton, Southampton SO16 7PX, UK. vhp@soton.ac.uk
Abstract:
It is well known that systemic infections cause flare-ups of disease in individuals with asthma and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration.
More Related Videos
Related Concept Videos
Bacterial Meningitis II: Pathophysiology
Chronic Inflammation: Introduction
Encephalitis ll: Pathophysiology
Inflammation
Disorders of the Nervous Tissue
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Acute Inflammation III: Local and Systemic Effects

