Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding
Abid Khan1, Jon D Silversides, Leigh Madden
1Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK HU6 7RX.
Abstract:
The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.


