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Updated: Jul 17, 2026

A Periprosthetic Joint Candida albicans Infection Model in Mouse
Published on: February 2, 2024
[The treatment of periprosthetic infections]
C H Lohmann1, M Fürst, O Niggemeyer
1Lehrstuhl für Orthopädie, Universitätsklinikum Hamburg-Eppendorf. LohmannCH@t-online.de
Abstract:
Periprosthetic infections are severe complications following total joint arthroplasty. The infection rate is estimated to be 0.5-2%. Systemic diseases such as rheumatoid arthritis and previous surgery are considered risk factors for infection. The infection rate in the present patient cohort was low (0.72%). The recurrence rate (23.4%) is due to patients with rheumatoid arthritis and septic total knee arthroplasties. Successful treatment is dependent on various factors, one of which involves accurate preoperative bacterial diagnostics. Joint fluid aspiration is the appropriate procedure. Open biopsy or arthroscopically guided biopsy can be performed in cases of unclear diagnostic results. Early infection can be treated with thorough joint debridement without exchanging fixed implant components; "low-grade" or late infections require revision with implant removal in a one or two stage septic revision according to clearly determined algorithms. Antibiotic therapy is mandatory, and a combination with rifampicin is a very useful basis.
Insights
Periprosthetic joint infections (PJIs) are serious complications after total joint arthroplasty. Accurate diagnosis and tailored treatment, including debridement or revision surgery and antibiotic therapy, are crucial for successful outcomes.
Area of Science:
- Orthopedics
- Infectious Diseases
- Microbiology
Context:
- Periprosthetic joint infections (PJIs) are significant complications following total joint arthroplasty (TJA).
- Risk factors include systemic diseases like rheumatoid arthritis and prior surgeries.
- The incidence of PJIs in the studied cohort was 0.72%, with a recurrence rate of 23.4%.
Purpose:
- To review diagnostic and treatment strategies for periprosthetic joint infections.
- To highlight the importance of accurate preoperative bacterial diagnostics.
- To discuss management algorithms for early and late-stage infections.
Summary:
- Accurate preoperative diagnosis via joint fluid aspiration is essential for successful PJI management.
- Early infections may be treated with debridement, while late or low-grade infections necessitate revision surgery.
- Antibiotic therapy, particularly with rifampicin, is a mandatory component of treatment.
Impact:
- This review provides insights into optimizing the management of PJIs.
- It emphasizes the need for precise diagnostic methods and evidence-based treatment algorithms.
- Improved PJI management can lead to better patient outcomes and reduced healthcare costs.
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