Related Experiment Video
Updated: Jul 17, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
Published on: July 29, 2021
Atypical primary headache responding to finger pressure: possible involvement of the vagus nerve?
Fabrizio Di Stani1, Marco Calabresi, Marco Pappagallo
1Centro di Medicina del Dolore, Policlinico Umberto I University of Rome La Sapienza, Rome, Italy. fabrizio.distani@uniroma1.it
Abstract:
We describe a case of atypical primary headache strongly responsive to prolonged pressure in the anterior aspect of the neck. We hypothesize that, at least in this case, the trigemino-cervical system and its connections with the vagus nerve are involved.
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