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Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
Published on: June 25, 2019
Peripheral large nerve fibre function in patients with chronic plaque psoriasis
E Chroni1, S Georgiou, P Polychronopoulos
1Department of Neurology, University of Patras, Rio-Patras, Greece. echroni@yahoo.com
European Journal of Neurology
|January 16, 2007
Summary
This study investigated peripheral large nerve fibre function in psoriasis patients. Results show no measurable nerve abnormalities, suggesting psoriasis is not associated with peripheral large fibre neuropathy.
Area of Science:
- Neurology
- Dermatology
Background:
- Neurogenic inflammation is implicated in psoriasis pathogenesis.
- Peripheral neuropathy has been observed in some psoriasis patients.
Purpose of the Study:
- To determine if psoriasis patients exhibit impaired peripheral large nerve fibre function.
- To investigate the potential link between psoriasis and peripheral large fibre neuropathy.
Main Methods:
- Clinical neurological and standard neurophysiological examinations were performed.
- Included motor and sensory nerve conduction studies in upper and lower extremities.
- Compared 32 severe chronic plaque psoriasis patients with 32 healthy controls.
Main Results:
- Neurological examinations revealed no clinical signs of large fibre neuropathy.
- All neurophysiological parameters were within normal limits.
- No statistically significant differences were found between psoriasis patients and controls.
Conclusions:
- Psoriasis patients do not exhibit measurable abnormalities in peripheral large nerve fibres.
- The study does not support an association between psoriasis and peripheral large fibre neuropathy.
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