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Photo-onycholysis due to indapamide
Tim Rutherford1, Rodney Sinclair
1Monash Medical Centre, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia. timrutherford@hotmail.com
The Australasian Journal of Dermatology
|January 16, 2007
Summary
Photo-onycholysis, a nail condition, can be caused by the diuretic indapamide. This case highlights delayed onset due to artificial nails and resolution after drug withdrawal.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Hypertension is a common condition often managed with diuretics.
- Indapamide is a widely prescribed thiazide-like diuretic.
Observation:
- A 75-year-old woman developed photo-onycholysis.
- The condition was linked to indapamide treatment for hypertension.
- Artificial nails inadvertently masked the initial symptoms.
Findings:
- Photo-onycholysis occurred without a generalized photosensitive rash.
- Nail changes resolved after discontinuing indapamide.
- Opaque nail polish aided in recovery.
Implications:
- Indapamide can cause photo-onycholysis, a specific nail reaction.
- Photoprotective measures like artificial nails can delay diagnosis.
- Awareness is crucial for timely diagnosis and management of drug-induced photosensitivity.
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